The Epidermal Growth Factor Receptor Forms Location-Dependent Complexes in Resting Cells
نویسندگان
چکیده
منابع مشابه
The Epidermal Growth Factor Receptor Forms Location-Dependent Complexes in Resting Cells.
The epidermal growth factor receptor (EGFR) is a prototypical receptor tyrosine kinase involved in cell growth and proliferation and associated with various cancers. It is commonly assumed that after activation by binding of epidermal growth factor to the extracellular domain it dimerizes, followed by autophosphorylation of tyrosine residues at the intracellular domain. However, its oligomeriza...
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ژورنال
عنوان ژورنال: Biophysical Journal
سال: 2016
ISSN: 0006-3495
DOI: 10.1016/j.bpj.2016.09.049